|
Photoredox Catalysis
SET initiated molecular construction has experienced a recent surge within the research community. The field of photoredox catalysis has captained advances made in this field. The redox abilities of various complexes to reduce or oxidize various organic compounds from their excited states have opened up for the possibility to utilize low energy visible-light to mediate synthetic transformations. These operations are thus inherently energy efficient and provides very mild reaction conditions. Furthermore, functionalities can be engaged through novel mechanistic pathways which opens up for unprecedented reactivity patterns and thus strategies for efficiently achieving molecular complexity. As such, photoredox catalysis has proven to be a very power full synthetic approach that already has become a standard first option in many laboratories.
|
Carboxylic acid derivatives
|
Carboxylic acids are prevalent functionalities in nature and easily accessible in thousands of fine chemicals accessible commercially. We are targeting carboxylic acids and its derivatives as motifs for reaction initiation where the carbonyl functionality serves as redox mediators. Both reductive and oxidation approaches are investigated for fragmentation based carbon centered radical formations. These radicals, alkyl or acyl, are presently utilized in structural complexity generating endeavors.
|
Future directions
|
We will continue to explore the rich redox chemistry of carbonyl compounds in the context of photoredox catalysis but will also screen for novel reactivity for various functionalities achievable by SET initiation.
|
Examples of recent projects
Photocatalytic Decarboxylative Reduction of Carboxylic – Org. Lett. 2014
Acyl Radicals from Aromatic Carboxylic Acids – Angew. Chem. In. Ed. 2015
Visible-Light-Mediated Photocatalytic Difunctionalization of
Olefins by Radical Acylarylation and Tandem Acylation/
Semipinacol Rearrangement – Chem. Eur. J. 2016
